They serve to transmit sound-induced mechanical vibrations from the eardrum to the oval window of the fluid-filled cochlea. The air-filled middle ear contains the ossicles, which are three tiny bones (malleus, incus and stapes) linked by the incudomalleolar and incudostapedial diarthrodial joints. Contrarily, there are studies that dispute such a correlation. Children with juvenile chronic arthritis are also more susceptible to HL. These comparative case-control studies were conducted globally in the U.S., U.K., Spain, Italy, Japan, India, etc., and they covered over 900 RA subjects. In humans, correlative studies reported that hearing loss occurs more frequently in RA patients than in normal individuals. A primary symptomatic hallmark of RA is erosion of the arthrodial joints. Rheumatoid arthritis is a systemic disease characterized by generalized inflammation and destruction of cartilage and bone. Considering the fact that certain anti-inflammatories are ototoxic in high doses, monitoring RA patients’ auditory function is advisable as part of the effort to ensure their well-being. Whether the inner ear sustains bone erosion or other pathology, and whether the cochlear nerve sustains pathology await subsequent studies. This combination suggests that conductive impairment is at least part of the etiology of RA-induced HL in a murine model. The observed bone defects in the middle ear that were accompanied by changes in ABR responses were consistent with conductive HL. The absolute latencies of all ABR waves were prolonged, but mean interpeak latencies were not statistically different. Additionally, a significant narrowing of the incudostapedial joint space and an increase in the porosity of the stapes were observed. RA mice exhibited significantly decreased hearing sensitivity compared to age-matched controls. Diarthrodial joints in the middle ear were examined with microcomputer tomography (microCT), and hearing function was assessed by auditory brainstem response (ABR). The aim of this study was to determine the association between bone damage to the ossicles of the middle ear and HL, using a widely accepted murine model of collagen-induced arthritis (RA mice). However, experimental evidence that supports this hypothesis is still lacking because the human auditory organ is not readily accessible. The stapes bone helps to transmit and amplify sound vibrations from the incus bone to the inner ear.Globally, a body of comparative case-control studies suggests that rheumatoid arthritis (RA) patients are more prone to developing hearing loss (HL). It is also known as the stirrup bone because of its shape. The stapes bone is the smallest bone in the human body. The incus bone helps to transmit and amplify sound vibrations from the eardrum to the inner ear. It is also known as the anvil bone because of its shape. The incus bone is one of three small bones in the middle ear. The malleus bone is named for its hammer-like shape and is essential for normal hearing. It is one of three bones in the middle ear that help to transmit sound from the eardrum to the inner ear. The malleus bone is a small bone in the middle ear that is also known as the hammer. These bones play a crucial role in the process of hearing. They transmit sound vibrations from the eardrum to the inner ear, amplifying the sound along the way. The auditory ossicles are three small bones in the middle ear: the malleus (hammer), incus (anvil), and stapes (stirrup).
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